Les effets secondaires du vaccin anti-hépatite B

mercredi 9 juin 2010
par  administrateur
popularité : 10%

De nombreux effets secondaires ont été décrits dans la littérature internationale :

- complications neurologiques :

  • maladies démyélinisantes (HERROELEN L. et al. 1991) [1], (KAPLANSKI G. et al. 1995) [2], (MANNA R. et al. 1996) [3]
  • myélite transverse (MAHASSIN F. et al. 1993) [4], (SENEJOUX A. et al. 1996) [5], (TREVISANI F. et al. 1993) [6]
  • sclérose en plaque (NADLER J. P. 1993) [7] , (HERNAN M.A. et al. 2004) [8]  [9]
  • leucoencéphalite (MANNA R. et al. 1996) [10]
  • sclérose latérale amyotrophique (S.L.A.) ou maladie de CHARCOT
  • ataxie cérébelleuse aigüe (DEISENHAMMER F. et al. 1994) [11]
  • polyneuropathie (RIBERA E.F. et al. 1983) [12]
  • amyotrophie (REUTENS D.C. et al. 1990) [13]
  • myasthénie (BIRON P. et al. 1988) [14]
  • paralysie faciale (GANRY O. et al. 1992) [15]

- complications oculaires :

  • occlusion de la veine centrale de la rétine (GRANEL B. et al.) [16]
  • uvéite (FRIED M. et al. 1987) [17]
  • perte de vision (BREZIN A.P. 1993) [18]
  • neuro-papillite (BERKMAN N. et al. 1996) [19], (BERKMAN N. 1997) [20]

- complications ORL :

  • surdité par atteinte de l’oreille interne (BONFILS P. et al. 1996) [21], (BIACABE et al. 1997) [22]

- mort subite du nourrison (NIU M.T. et al 1999) [23]
 : entre 1991 et 1998, 18 cas [24] de mort subite ont été recensés aux Etats-Unis, avec une moyenne d’âge de 2 jours (le vaccin est administré à la naissance aux USA).

- complications rhumatologiques :

  • arthrite (HACHULLA et al. 1990) [25], (ROGERSON S. J, NYE F.J. 1990) [26], (HASSAN W. et al. 1994), [27] , (VAUTIER G. 1994) [28], (GROSS K. et al. 1995) [29], (CATHEBRAS P. et al. 1996) [30], (SOUBRIER M. et al. 1997) [31], (BRACCI 1997) [32].

- complications dermatologiques :

  • lichen plan (AUBIN F. et al. 1994) [33], (TREVISAN G. et al. 1993) [34]
  • érythème noueux (GOOLSBY P. 1989) [35], (ROGERSON S. J, NYE F.J. 1990) [36], (DI GIUSTO C.A., BERNHARD J.D.) [37]
  • érythème multiforme (MILSTIEN J.B. 1986) [38], (DI LERNIA V. et al. 1986) [39], (CASTRESANA 1993) [40], (LOCHE et al. 2000) [41]
  • alopécie (WISE R.P. et al. 1997) [42]

- complications rénales :

  • glomérulonéphrites (MACARIO F. et al.) [43]
  • lupus érythémateux disséminé (L.E.D.) (TUDELA P. et al. 1992) [44], (MAMOUX V., DUMONT C. 1994) [45], (GUISERIX J.1996) [46], (FINIELZ 1998) [47]

- complications cardio-vasculaires :

  • vascularite, vasculite (ALLEN M. B. et al. 1993) [48] , (NEAU D. et al. 1996) [49]
  • panartérite noueuse (P.A.N.) (LEGOFF. et al. 1988) [50]
  • péricardite (BENSAÏD J., DENIS F. 1993) [51]

- complications hématologiques :

  • thrombopénie (MEYBOOM R.H. et al.1995) [52] (NEAU et al. 1988) [53]
  • purpura thrombopénique (POULLIN P., GABRIEL B. 1994) [54]
  • anémie hémolytique (MARTINEZ E. et al. 1992) [55]
  • aplasie médullaire (VIALLARD J.F et al. 2000) [56], (SHENOY K.A. et al. 2001) [57]
  • leucémie  ? (MA X. et al) [58]

- recrudescence de diabète de type 1 (diabète insulinodépendant) ? (CLASSEN J.B. 1996) [59]


[1

Herroelen, L., de Keyser, J., & Ebinger, G. (1991). Central-nervous-system demyelination after immunisation with recombinant hepatitis B vaccine. Lancet, 338(8776), 1174–1175.
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[2

Kaplanski, G., Retornaz, F., Durand, J., & Soubeyrand, J. (1995). Central nervous system demyelination after vaccination against hepatitis B and HLA haplotype. J Neurol Neurosurg Psychiatry, 58(6), 758–759.
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[3

Manna, R., De Santis, A., Oliviero, A., Carnevale, A., Caputo, S., Pahor, M., et al. (1996). Leukoencephalitis after recombinant hepatitis B vaccine. J Hepatol, 24(6), 764–765.
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[4

Mahassin, F., Algayres, J. P., Valmary, J., Bili, H., Coutant, G., Bequet, D., et al. (1993). [Acute myelitis after vaccination against hepatitis B]. Presse Med, 22(40), 1997–1998.
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[5

Senejoux, A., Roulot, D., Belin, C., Tsakiris, L., Rautureau, J., & Coste, T. (1996). [Acute myelitis after immunization against hepatitis B with recombinant vaccine]. Gastroenterol Clin Biol, 20(4), 401–402.
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[6

Trevisani, F., Gattinara, G. C., Caraceni, P., Bernardi, M., Albertoni, F., D'Alessandro, R., et al. (1993). Transverse myelitis following hepatitis B vaccination. J Hepatol, 19(2), 317–318.
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[7

Nadler, J. P. (1993). Multiple sclerosis and hepatitis B vaccination. Clin Infect Dis, 17(5), 928–929.
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[8

Hernan, M. A., Jick, S. S., Olek, M. J., & Jick, H. (2004). Recombinant hepatitis B vaccine and the risk of multiple sclerosis: a prospective study. Neurology, 63(5), 838–842.
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[9Voir également les auteurs en références à la rubrique "maladies démyélinisantes".

[10

Manna, R., De Santis, A., Oliviero, A., Carnevale, A., Caputo, S., Pahor, M., et al. (1996). Leukoencephalitis after recombinant hepatitis B vaccine. J Hepatol, 24(6), 764–765.
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[11

Deisenhammer, F., Pohl, P., Bosch, S., & Schmidauer, C. (1994). Acute cerebellar ataxia after immunisation with recombinant hepatitis B vaccine. Acta Neurol Scand, 89(6), 462–463.
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[12

Ribera, E. F., & Dutka, A. J. (1983). Polyneuropathy associated with administration of hepatitis B vaccine. N Engl J Med, 309(10), 614–615.
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[13

Reutens, D. C., Dunne, J. W., & Leather, H. (1990). Neuralgic amyotrophy following recombinant DNA hepatitis B vaccination. Muscle Nerve, 13(5), 461.
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[14

Biron, P., Montpetit, P., Infante-Rivard, C., & Lery, L. (1988). Myasthenia gravis after general anesthesia and hepatitis B vaccine. Arch Intern Med, 148(12), 2685.
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[15

Ganry, O., Lerailler, F., Vercelletto, M., Chiffoleau, A., & Larousse, C. (1992). [Peripheral facial paralysis following vaccination against hepatitis B. Apropos of a case]. Therapie, 47(5), 437–438.
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[16

Granel, B., Disdier, P., Devin, F., Swiader, L., Riss, J. M., Coupier, L., et al. (1997). [Occlusion of the central retinal vein after vaccination against viral hepatitis B with recombinant vaccines. 4 cases]. Presse Med, 26(2), 62–65.
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[17

Fried, M., Conen, D., Conzelmann, M., & Steinemann, E. (1987). Uveitis after hepatitis B vaccination. Lancet, 2(8559), 631–632.
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[18

Brezin, A., Lautier-Frau, M., Hamedani, M., Rogeaux, O., & Hoang, P. L. (1993). Visual loss and eosinophilia after recombinant hepatitis B vaccine. Lancet, 342(8870), 563–564.
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[19

Berkman, N., Benzarti, T., Dhaoui, R., & Mouly, P. (1996). [Bilateral neuro-papillitis after hepatitis B vaccination]. Presse Med, 25(28), 1301.
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[20

Berkman, N. (1997). [A case of segmentary unilateral occlusion of the central retinal vein following hepatitis B vaccination]. Presse Med, 26(14), 670.
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[21

Bonfils, P., Biacabe, B., Potard, G., & Aidan, D. (1996). [Fluctuant perception hearing loss after hepatitis B vaccine]. Ann Otolaryngol Chir Cervicofac, 113(6), 359–361.
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[22

Biacabe, B., Erminy, M., & Bonfils, P. (1997). A case report of fluctuant sensorineural hearing loss after hepatitis B vaccination. Auris Nasus Larynx, 24(4), 357–360.
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[23

Niu, M. T., Salive, M. E., & Ellenberg, S. S. (1999). Neonatal deaths after hepatitis B vaccine: the vaccine adverse event reporting system, 1991-1998. Arch Pediatr Adolesc Med, 153(12), 1279–1282.
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[24C’est peu mais on sait aussi que seulement 1% des accidents iatrogènes sont rapportés aux centres de pharmacovigilance.

[25

Hachulla, E., Houvenagel, E., Mingui, A., Vincent, G., & Laine, A. (1990). Reactive arthritis after hepatitis B vaccination. J Rheumatol, 17(9), 1250–1251.
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[26

Rogerson, S. J., & Nye, F. J. (1990). Hepatitis B vaccine associated with erythema nodosum and polyarthritis. Bmj, 301(6747), 345.
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[27

Hassan, W., & Oldham, R. (1994). Reiter's syndrome and reactive arthritis in health care workers after vaccination. Bmj, 309(6947), 94.
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[28

Vautier, G., & Carty, J. E. (1994). Acute sero-positive rheumatoid arthritis occurring after hepatitis vaccination. Br J Rheumatol, 33(10), 991.
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[29

Gross, K., Combe, C., Kruger, K., & Schattenkirchner, M. (1995). Arthritis after hepatitis B vaccination. Report of three cases. Scand J Rheumatol, 24(1), 50–52.
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[30

Cathebras, P., Cartry, O., Lafage-Proust, M. H., Lauwers, A., Acquart, S., Thomas, T., et al. (1996). Arthritis, hypercalcemia, and lytic bone lesions after hepatitis B vaccination. J Rheumatol, 23(3), 558–560.
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[31

Soubrier, M., Dubost, J. J., Bielsa, C., Ristori, J. M., & Bussiere, J. L. (1997). [Erosive polyarthritis triggered by vaccination against hepatitis B]. Presse Med, 26(2), 75.
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[32

Bracci, M., & Zoppini, A. (1997). Polyarthritis associated with hepatitis B vaccination. Br J Rheumatol, 36(2), 300–301.
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[33

Aubin, F., Angonin, R., Humbert, P., & Agache, P. (1994). Lichen planus following hepatitis B vaccination. Arch Dermatol, 130(10), 1329–1330.
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[34

Trevisan, G., & Stinco, G. (1993). Lichen ruber planus following HBV vaccination. Acta Derm Venereol, 73(1), 73.
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[35

Goolsby, P. L. (1989). Erythema nodosum after Recombivax HB hepatitis B vaccine. N Engl J Med, 321(17), 1198–1199.
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[36

Rogerson, S. J., & Nye, F. J. (1990). Hepatitis B vaccine associated with erythema nodosum and polyarthritis. Bmj, 301(6747), 345.
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[37

Di Giusto, C. A., & Bernhard, J. D. (1986). Erythema nodosum provoked by hepatitis B vaccine. Lancet, 2(8514), 1042.
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[38

Milstien, J. B., & Kuritsky, J. N. (1986). Erythema multiforme and hepatitis B immunization. Arch Dermatol, 122(5), 511–512.
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[39

Di Lernia, V., Lo Scocco, G., & Bisighini, G. (1994). Erythema multiforme following hepatitis B vaccine. Pediatr Dermatol, 11(4), 363–364.
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[40

Castresana-Isla, C. J., Herrera-Martinez, G., & Vega-Molina, J. (1993). Erythema nodosum and Takayasu's arteritis after immunization with plasma derived hepatitis B vaccine. J Rheumatol, 20(8), 1417–1418.
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[41

Loche, F., Schwarze, H. P., Thedenat, B., Carriere, M., & Bazex, J. (2000). Erythema multiforme associated with hepatitis B immunization. Clin Exp Dermatol, 25(2), 167–168.
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[42

Wise, R. P., Kiminyo, K. P., & Salive, M. E. (1997). Hair loss after routine immunizations. Jama, 278(14), 1176–1178.
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[43

Macario, F., Freitas, L., Correia, J., Campos, M., & Marques, A. (1995). Nephrotic syndrome after recombinant hepatitis B vaccine. Clin Nephrol, 43(5), 349.
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[44

Tudela, P., Marti, S., & Bonal, J. (1992). Systemic lupus erythematosus and vaccination against hepatitis B. Nephron, 62(2), 236.
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[45

Mamoux, V., & Dumont, C. (1994). [Lupus erythematosus disseminatus and vaccination against hepatitis B virus]. Arch Pediatr, 1(3), 307–308.
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[46

Guiserix, J. (1996). Systemic lupus erythematosus following hepatitis B vaccine. Nephron, 74(2), 441.
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[47

Finielz, P., Lam-Kam-Sang, L. F., & Guiserix, J. (1998). Systemic lupus erythematosus and thrombocytopenic purpura in two members of the same family following hepatitis B vaccine. Nephrol Dial Transplant, 13(9), 2420–2421.
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[48

Allen, M. B., Cockwell, P., & Page, R. L. (1993). Pulmonary and cutaneous vasculitis following hepatitis B vaccination. Thorax, 48(5), 580–581.
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[49NEAU D. et al., Vascularite grave après vaccination contre l’hépatite B : une observation, Revue de médecine interne, 1996, tome 17 (suppl. 1), p. 142s.

[50LEGOFF. P et al., Périartérite noueuse après vaccination contre l’hépatite B, La Presse médicale, 1988, p. 1763.

[51

Bensaid, J., & Denis, F. (1993). [Benign acute pericarditis after vaccination against hepatitis B]. Presse Med, 22(6), 269.
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[52

Meyboom, R. H., Fucik, H., & Edwards, I. R. (1995). Thrombocytopenia reported in association with hepatitis B and A vaccines. Lancet, 345(8965), 1638.
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[53

Neau, D., Bonnet, F., Michaud, M., Perel, Y., Longy-Boursier, M., Ragnaud, J. M., et al. (1998). Immune thrombocytopenic purpura after recombinant hepatitis B vaccine: retrospective study of seven cases. Scand J Infect Dis, 30(2), 115–118.
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[54

Poullin, P., & Gabriel, B. (1994). Thrombocytopenic purpura after recombinant hepatitis B vaccine. Lancet, 344(8932), 1293.
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[55

Martinez, E., & Domingo, P. (1992). Evans's syndrome triggered by recombinant hepatitis B vaccine. Clin Infect Dis, 15(6), 1051.
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[56

Viallard, J. F., Boiron, J. M., Parrens, M., Moreau, J. F., Ranchin, V., Reiffers, J., et al. (2000). Severe pancytopenia triggered by recombinant hepatitis B vaccine. Br J Haematol, 110(1), 230–233.
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[57

Ashok Shenoy, K., Prabha Adhikari, M. R., Chakrapani, M., Shenoy, D., & Pillai, A. (2001). Pancytopenia after recombinant hepatitis B vaccine--an Indian case report. Br J Haematol, 114(4), 955.
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[58

Ma, X., Does, M. B., Metayer, C., Russo, C., Wong, A., & Buffler, P. A. (2005). Vaccination history and risk of childhood leukaemia. Int J Epidemiol, 34(5), 1100–1109.
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[59

Classen, J. B. (1996). Childhood immunisation and diabetes mellitus. N Z Med J, 109(1022), 195.
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